Gabriel Mckinsey, PhD

Asst Professional Researcher
Pediatrics
[email protected]
+1 734 262-5689

Hello! My name is Gabriel McKinsey. I’m currently a Professional Researcher in Dr. Thomas Arnold’s lab in the UCSF Department of Pediatrics and the UCSF Neonatal Brain Research Institute. My research focuses on the embryonic and neonatal development of the neuroimmune system. In particular, I study the role of Itgb8-mediated TGF-B signaling in the development and homeostasis of microglia and other brain macrophages. I have also done work in Tom’s lab focusing on the study of brain fibroblast/macrophage interactions in development and disease. My work leverages the use of cutting edge molecular and genetic tools (some of which we have created, see McKinsey et al. eLife 2020) to dissect and define the signaling pathways and cellular interactions necessary for proper neuroimmune development.

 

I am currently on the faculty job market and am eager to start my own independent research group! Please feel free to reach out if you have any questions about my work or if you would like to know more about my future plans as an independent investigator.

 

My email is gabriel DOT mckinsey AT ucsf.edu. 

Publications: 

Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism.

Neuron

Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R

A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models.

Cell reports

Bedolla AM, McKinsey GL, Ware K, Santander N, Arnold TD, Luo Y

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.

Nature immunology

Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O

Radial glia promote microglial development through integrin α V β 8 -TGFβ1 signaling.

bioRxiv : the preprint server for biology

McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky O, Arnold TD

Finding the right tool: a comprehensive evaluation of microglial inducible cre mouse models.

bioRxiv : the preprint server for biology

Bedolla A, Mckinsey G, Ware K, Santander N, Arnold T, Luo Y

Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.

Proceedings of the National Academy of Sciences of the United States of America

Su-Feher L, Rubin AN, Silberberg SN, Catta-Preta R, Lim KJ, Ypsilanti AR, Zdilar I, McGinnis CS, McKinsey GL, Rubino TE, Hawrylycz MJ, Thompson C, Gartner ZJ, Puelles L, Zeng H, Rubenstein JLR, Nord AS

Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.

The Journal of clinical investigation

Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD

A new genetic strategy for targeting microglia in development and disease.

eLife

McKinsey GL, Lizama CO, Keown-Lang AE, Niu A, Santander N, Larpthaveesarp A, Chee E, Gonzalez FF, Arnold TD

Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons.

Cell reports

McGregor MM, McKinsey GL, Girasole AE, Bair-Marshall CJ, Rubenstein JLR, Nelson AB

Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons.

Cell reports

Lindtner S, Catta-Preta R, Tian H, Su-Feher L, Price JD, Dickel DE, Greiner V, Silberberg SN, McKinsey GL, McManus MT, Pennacchio LA, Visel A, Nord AS, Rubenstein JLR

Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.

Cell reports

Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR

Neural control of sexually dimorphic social behaviors.

Current opinion in physiology

McKinsey G, Ahmed OM, Shah NM

Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate.

Neuron

Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein JLR

Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.

Neuron

Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH

Many human accelerated regions are developmental enhancers.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Capra JA, Erwin GD, McKinsey G, Rubenstein JL, Pollard KS

A high-resolution enhancer atlas of the developing telencephalon.

Cell

Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch RV, McKinsey GL, Pattabiraman K, Silberberg SN, Blow MJ, Hansen DV, Nord AS, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Kaplan T, Kriegstein AR, Rubin EM, Ovcharenko I, Pennacchio LA, Rubenstein JL

Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.

Neuron

McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL

Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons.

Molecular and cellular neurosciences

Potter GB, Petryniak MA, Shevchenko E, McKinsey GL, Ekker M, Rubenstein JL